No, you dont NEED it, at all. Many people don’t like the ‘flush’ you get when you take Niacin, but it is part of the process.
Paul Stamets reports that the majority of neurogenesis occurs in the nerve extremities; since niacin works as a flushing agent and causes vasodilation (expansion of the blood vessels), it has the potential to carry the molecules of other compounds across the blood-brain barrier and into the farthest reaches of the nervous system; Stamets theorizes that this helps distribute the psilocybin and Lion’s Mane deeper into the brain and nervous system, enhancing their healing potential.
When is taking niacin not recommended:
- Hypersensitivity to vitamin B3
- Liver diseases
- Ulcerus pepticum (ulcer of stomach and/or duodenum)
- Gout
- Alcoholism
- Very low blood pressure
- Decreased kidney function
- Diabetes

